| abstract |
The present invention provides pharmaceutical formulations suitable for targeting specific tissues and / or organ (s) with the active ingredient formulated, for example when administered upstream of a target organ or tissue, and the use of such formulations in therapy, such formulations. It relates to a method of treatment by administration and a method for producing the same. The pharmaceutical formulation of the present invention is for parenteral administration to a target tissue, comprising particles containing the active ingredient and biodegradable polymer excipient, wherein at least 90% of the particles have a diameter of 10-20 microns and the formulation is 50 microns Substantially free of particles with diameters greater than and less than 5 microns limits the ability to pass through the target tissue and switch to the body circulation when the formulation is administered upstream of the target tissue. |