| abstract |
The present invention relates to a gene carrier comprising nanoparticles. More specifically, (a) nanoparticles; (b) oligonucleotides as universal binding parts covalently linked to the nanoparticle surface; And (c) (i) a complementary oligonucleotide as a binding counter-partner comprising a sequence complementary to said binding partner, and (ii) an inhibition having a sequence complementary to a target gene to reduce expression. It relates to a gene carrier comprising a cargo (cargo) comprising an inducing molecule having the sequence of the molecule (inhibitory molecule) or the target gene to induce expression. The present invention is a system capable of easily transporting DNA and RNA having sequences of aptamers, siRNAs, shRNAs, miRNAs, ribozymes, DNAzymes, PNAs or genes as well as antisense oligonucleotides into cells. In addition, the present invention knocks down the expression of target genes more efficiently than commercially available gene transfer reagents. |