| abstract |
Disclosed herein are soft tissue fillers, such as dermal and subcutaneous fillers, based on hyaluronic acid and pharmaceutically acceptable salts thereof. In one aspect, the hyaluronic acid-based composition described herein comprises a therapeutically effective amount of at least one anesthetic, eg lidocaine. For example, upon exposure to sterilization techniques or for long term storage, the hyaluronic acid-based compositions of the present invention comprising lidocaine have improved stability compared to conventional compositions comprising lidocaine. Methods and processes for the preparation of such hyaluronic acid-based compositions are also provided. |