| abstract |
Purine compounds of formula (I), and their stereoisomers, geometric isomers, tautomers, solvates, metabolites, and pharmaceutically acceptable salts thereof, inhibit lipid kinases including p110 alpha and other PI3K isoforms, and It is useful for treating disorders mediated by, for example, cancer. Disclosed are methods of using the compounds of formula (I) for the in vitro, in situ and in vivo diagnosis, prevention or treatment of such disorders, or related pathological symptoms in mammalian cells. |