| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03e703da3bbfd872ad355a2c3a5fe568 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9645
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-224 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-644
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21022 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 |
| filingDate |
2009-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c31442cde8d6728f79f5b384e0668dff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b15412dbdd79e45f0207aaf3992ae077 |
| publicationDate |
2011-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20110036071-A |
| titleOfInvention |
Factor IX variants with coagulation activity in the absence of their cofactors and their use for treating bleeding diseases |
| abstract |
The present invention is a variant of the vitamin K-dependent serine protease of the coagulation cascade, preferably a variant of Factor IX (F.IX), characterized in that the variant has a coagulation activity in the absence of its cofactor. The invention also relates to the use of these variants for the treatment and / or prevention of hemophilia caused or complexed by inhibitory antibodies to hemorrhagic disease, in particular hemophilia A and / or hemophilia B or F.VIII. The present invention also relates to additional variants of Factor IX (F.IX) that have the desired properties and can be tailored for each specific therapeutic application. |
| priorityDate |
2008-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |