| abstract |
Copolymers, and methods of making and using such copolymers, are described herein. Such copolymers have two or more blocks: a first block with one or more units that are hydrophilic at physiological pH, and a second block with hydrophobic groups. This second block further has one or more units with groups that are anionic at approximately physiological pH. The described copolymers disrupt cell membranes such as extracellular membranes, intracellular membranes, vesicles, organelles, endosomes, liposomes, or erythrocytes. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In certain instances, the copolymer is endosomal soluble. |