| abstract |
The present invention is SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6, or have an amino acid number substituted in the sequence as shown below: 0 to 3 (SEQ ID No. 1) in CDR1, 0 to 2 (SEQ ID No. 2) in CDR2, 0 to 0 in CDR3 2 (SEQ ID No. 3), 0 or 1 in CDR4 (SEQ ID No. 4), 0 to 4 in CDR5 (SEQ ID No. 5), or 0 to 2 in CDR6 (SEQ ID No. 6), or SEQ ID NO. 1 to SEQ ID No. A ligand comprising each complementarity determining region (CDRs) represented by a sequence having amino acids substituted with other amino acids having equivalent chemical function and properties in the 6 sequences. |