| abstract |
The present invention provides novel compounds, isomers or pharmaceutically acceptable salts thereof that act as vanilloid receptor 1 (VR1; TRPV1) antagonists; And it relates to a pharmaceutical composition comprising the same. The invention includes pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorders, urinary bladder hypersensitiveness, hypersensitivity Irritable bowel syndrome, fecal urgency, respiratory disorders, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, It provides a pharmaceutical composition for the prevention or treatment of diseases such as inflammatory diseases (ear diseases), ear disease (heartdisease) and the like. |