| abstract |
The present invention relates to novel products and salts of the formula (I) in all isomeric forms as medicaments. <Formula I> Where Het represents an aromatic or partially unsaturated, monocyclic or bicyclic heterocycle containing 1 to 4 heteroatoms N, O or S and optionally substituted with the same or different R 1 or R ′ 1, R is X- (AB) n -CONH 2 , X- (AB) n -O-CONH 2 , X- (AB) n -NH-CONH 2 , X- (CH 2 ) m -heterocycloalkyl, X- (CH 2 ) m -aryl and X- (CH 2 ) m -heteroaryl, where X is -OC (O), -NH-C (O), NH-CS, -NH-CO-CH 2 -O -, -NH-CO-CH 2 -S-CH 2 -CO-NH-, -NH-CO- (CH 2 ) 2 -SO 2 -and -NH-CO-CH 2 -N (CH 3 ) -CO -And A and B are the same or different and each is a single bond, CH 2 , CH-alkyl and CH-aralkyl, n is 1 or 2 and m is 0 or 1; R 1 and / or R ′ 1 are H, halogen, CF 3 , nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, and free or esterified with alkyl Carboxyl, carboxamide, CO-NH (alkyl), CON (alkyl) 2 , NH-CO-alkyl, sulfonamide, NH-SO 2 -alkyl, S (O) 2 -NHalkyl and S (O 2 ) -N (alkyl) 2 group, and all such alkyl, alkoxy and alkylthio groups are themselves optionally substituted. |