abstract |
A pyrimidone derivative or a salt thereof, or a solvate thereof or a hydrate thereof represented by the formula (I) in free base form or in addition salt form with an acid. Therapeutic use. <Formula I> Wherein, X is a methylene, NH, or C (O) -O- (C 1 -6 - alkyl) represents a nitrogen atom substituted by a; R1 is 2, 3 or 4-pyridine ring or a 2, 4 or 5 represents a pyrimidine ring, wherein said ring is optionally substituted by C 1 -6 alkyl, C 1 -6 alkoxy group or a halogen atom; R2 is hydrogen atom, C 1 -6 alkyl group or a halogen atom; R3 is an optionally substituted C 1 -6 alkyl group; R4 represents a hydrogen atom, a halogen atom, a hydroxyl group, or a C 1 -6 alkyl group; When X is a methylene or m is represented 1 to 2, X is NH, or C (O) -O- - if it is a nitrogen atom substituted by a (C 1 -6 alkyl) m represents 2. |