| abstract |
Pyrimido isoquinoline derivatives represented by formula (I) in free base form or in addition salt form with acids. Compounds of formula (I) are useful for the treatment of neurodegenerative diseases caused by abnormal GSK3β activity. <Formula I> In which R 1 represents a 4-pyridine ring or a 4-pyrimidine ring; R2 represents a hydrogen atom; R 3 represents a hydrogen atom; R4 is a hydrogen atom; Halogen atom; R7, R8, R9, R10 independently represent hydrogen atom, a halogen atom, a C 1 -6 alkoxy, nitro, hydroxyl or an amino; Formula II represents a single bond or a double bond. <Formula II> |