Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_17c6c7da627b7bead7208250127b52c2 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-13 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4418 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
filingDate |
2009-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8deee35992892be659ec623193baa63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf42b318186016b108d289e9d1a97d33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a270f110d64ed1853e8830eeac877624 |
publicationDate |
2011-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20110027314-A |
titleOfInvention |
Composition for the prevention and treatment of TF-α mediated diseases |
abstract |
The present invention relates to a composition for the prevention and treatment of TNF-α (tumor necrosis factor-α) mediated diseases comprising a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, Compounds inhibit the secretion of TNF-α by inhibiting the binding of HuR protein to the ARE (AU-rich element) region present in TNF-α mRNA, thereby reducing mRNA half-life, thereby treating TNF-α-mediated diseases and It can be usefully used as a prophylactic agent.n n n n n n n n [Formula 1]n n n Wheren n n R1 is ,n n n R2 is to be. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109563043-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-038355-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017216727-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2017283790-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10975056-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109563043-A |
priorityDate |
2009-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |