| abstract |
The present invention provides binding proteins that specifically bind to human interleukin-21 receptor (IL-21R) and antigen-binding fragments thereof (including human antibodies) and methods for their preparation. The binding protein can, for example, act as an antagonist of IL-21R activity to modulate an immune response, in particular an immune response mediated by IL-21R. The disclosed compositions and methods can be used, for example, in the diagnosis, treatment and / or prevention of IL-21R-related diseases such as inflammatory diseases, autoimmune diseases, allergies, graft rejection and other immune system diseases. |