| abstract |
Compositions for administration to the lung include fluoroquinolone betaines, such as ciprofloxacin betaine, and excipients. In one variation, the particles have a mass median aerodynamic diameter of about 1 μm to about 5 μm and the fluoroquinolone has a half-life in the lung of at least 1.5 hours. The composition is useful for the treatment of intrabronchial infections such as Pseudomonas aeruginosa, and particularly for the treatment of cystic fibrosis. |