| abstract |
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. Sirtuin-modulating compounds increase the lifespan of cells and, for example, diseases or disorders associated with aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, disorders of blood clotting, inflammation, cancer and / or flushing, and It can be used to treat and / or prevent a wide variety of diseases and disorders, including diseases or disorders that benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound with another therapeutic agent. |