| abstract |
Compounds of Formula (I) or pharmaceutically acceptable salts thereof, methods for their preparation, compositions containing them, and their use in the treatment of diseases and conditions in which antagonism of NK 1 is beneficial are provided: <Formula I> Where R is hydrogen or C 1-4 alkyl, R 1 is hydrogen, C 1-4 alkyl, C (O) OH, C (O) NH 2 or (C 1-4 alkylene) R 10 , R 2 and R 3 are independently hydrogen or C 1-4 alkyl, or R 2 and R 3 together with the carbon atom to which they are attached form a C 3-8 cycloalkyl group, R 4 is C 1-4 alkyl, C 1-4 alkoxy or halogen, R 5 and R 7 are independently hydrogen, hydroxy, halogen, C (O) NH 2 , C (O) OH or (C 1-4 alkylene) R 10 , R 6 and R 8 are independently hydrogen or halogen, R 9 is hydrogen, (C 1-4 alkylene) R 10 , C (O) NH 2 or C (O) OH, or R 9 together with R forms a 6 membered heterocyclic ring optionally containing an additional heteroatom selected from oxygen, sulfur or nitrogen, R 10 is hydrogen, halogen, hydroxy, C (O) NH 2, C (O) NH (C 1- 4 alkyl), C (O) N ( C 1- 4 alkyl) 2 or C (O) OH, and , n is 0, 1 or 2. |