| abstract |
The present invention provides metformin butyrate, a preparation method thereof, a pharmaceutical composition comprising the same, and a combination formulation. Metformin butyrate of the present invention is not only excellent in pharmacological effects compared to metformin hydrochloride, but can also achieve a therapeutic purpose by administering a lower dose than metformin hydrochloride. In addition, it has excellent physicochemical properties such as solubility, stability, hygroscopicity, anti-adhesion properties, and the like as a formulation, and thus may be usefully used as a pharmaceutically acceptable salt of metformin. |