| abstract |
Benzopyrans and benzoxepin compounds of Formulas I and II, stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts inhibit lipid kinases including p110 alpha and other isoforms of PI3K, It is useful for treating disorders such as cancer mediated by lipid kinases. Also disclosed are methods of using the compounds of formula (I) and (II) in diagnosing, preventing or treating such disorders, or related pathological conditions, of mammalian cells in vitro, in situ and in vivo. Formula I Formula II |