| abstract |
A 5-membered ring compound represented by formula (1) or a pharmaceutically acceptable salt thereof is disclosed. The compound inhibits the infiltration of leukocytes, including eosinophils and lymphocytes, and is effective as a drug for treating various inflammations. The compound is highly safe and can be administered for a long time. Also disclosed are pharmaceutical products comprising 5-membered ring compounds or pharmaceutically acceptable salts thereof. (Wherein, R 1 is being a halogen atom, or C 1 -C 3 alkyl or C 1 -C 3 alkoxy optionally substituted with phenyl; C 1 -C 3 where R 2 is optionally substituted with C 1 -C 3 alkyl An alkylene group or a carbonyl group; R 3 is a C 1 -C 3 alkyl group; R 4 and R 5 are independently a hydrogen atom or a C 1 -C 3 alkyl group; or -N (R 4 ) R 5 is C 1- May be a morpholino group which may be substituted with C 3 alkyl; Y 2 is a C 2 -C 4 alkylene group; and R 6 is a hydrogen atom, a halogen atom, a C 1 -C 3 alkyl group or a C 1 -C 3 alkoxy Term). |