| abstract |
A compound of formula 2; A compound of formula 3; Alkaline earth metal hydroxides of formula 4 (wherein M is Ca, Sr or Ba), alkali metal carbonates of formula 4a (wherein M 1 is Li, Na or K), 1,5-diazabicyclo [4.3.0 A base comprising at least one compound selected from the group consisting of] non-5-ene and 1,8-diazabicyclo [5.4.0] undes-7-ene; And distilling water from a mixture comprising an aprotic solvent capable of forming a low boiling point azeotrope with water, wherein Q and Z are as defined in the specification and claims. A manufacturing method is disclosed. (1) contacting a compound of formula 5 wherein X is Cl, Br or I with a magnesium metal or alkylmagnesium halide in the presence of an ether solvent to form a reaction mixture comprising a Grignard reagent derived (2) contacting the reaction mixture with a compound of formula 6 wherein Y is OR 11 or NR 12 R 13 and R 11 , R 12 and R 13 are as defined in the specification and claims Also disclosed are methods of preparing compounds of formula (2). Using the compound of formula 1 characterized in that the compound of formula 1 is prepared by the process disclosed above or using the compound of formula 1 prepared by the method disclosed above, Also disclosed are methods for the preparation of compounds of the same) as defined in the specification and claims. |