| abstract |
Novel heterocyclic compounds of formula (I), derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof This is described. These compounds include immunological diseases, inflammations, pain disorders, rheumatoid arthritis; osteoporosis; Multiple myelopathy; Uveitis; Acute and chronic myeloid leukemia; Atherosclerosis; cancer; Cajuncia; Ischemia-induced cell damage; Pancreatic beta cell destruction; Osteoarthritis; Rheumatoid spondylitis; Gouty arthritis; Inflammatory bowel disease; (ARDS); psoriasis; Crohn's disease; Allergic rhinitis; Ulcerative colitis; Anaphylaxis; Contact dermatitis; Muscle degeneration; asthma; COPD; Bone absorption disease; Multiple sclerosis; blood poisoning; Septic shock; It is useful for the treatment of toxic shock syndrome and fever. More specifically these compounds are useful as PDE4 inhibitors and for treating PDE4 mediated diseases. |