http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20100130984-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e9c7aafd38f03495838a1d404ef9fa5b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-62 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-62 |
| filingDate | 2009-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c0ffd06123b895f7147f5d1da43f539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a670aae225f834dc0fa9a31cca55ff6 |
| publicationDate | 2010-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20100130984-A |
| titleOfInvention | Short Fatty Acid Tail Polymyxin Derivatives and Their Uses |
| abstract | The present invention relates to a polymyxin derivative, wherein the derivative has three positive charges at physiological pH, and the terminal portion (D) of the derivative has one to five carbon atoms. The invention also relates to a combination product comprising at least the two derivatives. The present invention also provides a method for causing a Gram-negative bacterium to be sensitized to an antibiotic by simultaneously or sequentially administering a therapeutically effective amount of an antibiotic and a derivative according to the present invention; How to develop new antibiotics; And sensitizing clinically important bacteria to the complement of serum host defense mechanisms. The present invention also relates to a method for treating a Gram negative bacterial infection patient by administering the polymyxin derivative of the present invention in combination with a second antibiotic. Finally, the present invention relates to a method for preparing such polymyxin derivatives. |
| priorityDate | 2008-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 316.