| abstract |
The present invention relates to novel substances of the general formula (I) which are all isomeric forms and salts thereof, used as drugs: <Formula I> Where Het is a heterocycle optionally substituted with one or a plurality of radicals R1 or R'1, R is selected from the group comprising Formula II: <Formula II> R 1 and / or R ′ 1 described above are H, halogen, CF 3 , nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalkoxy, alkylthio, or free form. Carboxy, carboxamide, CO-NH (alkyl), CON (alkyl) 2 , NH-CO-alkyl, sulfonamide, NH-SO 2 -alkyl, S (O) 2 -NHalkyl, or esterified with alkyl or Selected from S (O 2 ) -N (alkyl) 2 radicals, wherein all radicals are optionally substituted, W1, W2 and W3 are independently CH or N, X is O, S, NR 2, C (O), S (O) or S (O) 2 , Z is optionally substituted H, HaI, -O-R2 or -NH-R2, wherein R2 is H, alkyl, cycloalkyl or heterocycloalkyl. |