| abstract |
Disclosed is a polysaccharide gel formulation comprising at least one polysaccharide degradation inhibitor and a method of making the same. The method includes providing at least one polysaccharide and incorporating at least one degradation inhibitor into the polysaccharide. In some embodiments, the incorporation step comprises: 1) mixing at least one inhibitor with at least one polysaccharide in a highly hydrated state to encapsulate the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network to release release kinetics or Controlling the final expansion ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor in a biocompatible or biodegradable vessel, and 2) combining the polysaccharide and the vessel in a gel formulation. The disclosed polysaccharide gel formulations can be used in a variety of cosmetic applications. |