abstract |
Pyrimidone derivatives or salts thereof, or solvates or hydrates thereof, and their therapeutic uses for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3β. <Formula I> Where Y is two hydrogen atoms, a sulfur atom, an oxygen atom, or C 1 -2 alkyl group, and represents a hydrogen atom; Z is a bond; Oxygen atom; A nitrogen atom substituted by a hydrogen atom or a C 1 -3 alkyl group; Sulfur atom; C 1 -6 alkyl group, a hydroxyl group, C 1 -6 alkoxy, C 1 -2 groups with one or two selected from perhalogenated alkyl group or an amino group represents an optionally substituted methylene; R1 is 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidin represents a pyrimidine ring, the ring is optionally substituted C 1 -6 alkyl, C 1 -6 alkoxy groups or halogen atoms; R2 is hydrogen atom, C 1 -6 alkyl group or a halogen atom; R3 represents a benzene ring or a naphthalene ring; The ring is optionally substituted; R4 is a hydrogen atom, C 1 -6 alkyl, C 3 -7 cycloalkyl group, C 3 -7-cycloalkyl -C 1 -6 alkyl, COO - represents a (C 1 -6 alkyl), these groups being optionally substituted; R5 represents a hydrogen atom or a C 1 -6 alkyl group; n represents 0-3. |