| abstract |
It has a strong GHS-R agonist action and provides a compound useful as a drug for treating systemic wasting diseases such as cachexia. General formula (1a) (Wherein X represents CH 2 , C═O, CH—OR, CH—SR or CH—NRR ′; m represents a number of 1 or 2; Ar represents a phenyl group, a naphthyl group, S, N, and O) It denotes a one or two 5 atomic aromatic heterocyclic cyclic group in the ring or 6-membered ring containing an element selected from; R 1 and R 2 are the same or different, represents a hydrogen atom or a methyl group; R 3 is C 1 N represents an alkyl group having 6 to 6, n represents a number of 0 or 1, R 4 and R 5 are the same or different and represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, etc. R 6 and R 7 , R And R 'is the same or different and represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms), 3,8-diaminotetrahydroquinoline derivative or salt thereof. |