| abstract |
The present invention relates to compounds of formula (I) The present invention also relates to a process for the preparation of the compound and its therapeutic use. <Formula I> Where A is a bond, an oxygen atom, or a -O-CH 2 -group; Ar 1 is a phenyl or heteroaryl group; Ar 2 is a phenyl, heteroaryl or heterocycloalkyl group; R 1a, b, c and R 2a, b, c are hydrogen or a halogen atom, or alkyl, cycloalkyl, -alkylcycloalkyl optionally substituted with one or more halogen atoms, -OR 5 (hydroxyl or alkoxy), hydroxyalkyl , Alkoxyalkyl, alkoxyalkoxy, halogenoalkyl, -O-halogenoalkyl, oxo, -CO-alkyl, -CO-alkyl-NR 6 R 7 , -CO-halogenoalkyl, -COOR 5 , -alkyl-COOR 5 , -O-alkyl-COOR 5 , -SO 2 -alkyl, -SO 2 -cycloalkyl, -SO 2 -alkylcycloalkyl, -SO 2 -alkyl-OR 5 , -SO 2 -alkyl-COOR 5 ,- SO 2 -alkyl-NR 6 R 7 , -SO 2 -halogenoalkyl, -alkyl-SO 2 -alkyl, -SO 2 -NR 6 R 7 , -SO 2 -alkyl-O-alkyl-OR 5 , -CONR 6 R 7 , -alkyl-CONR 6 R 7 or -O-alkyl-NR 6 R 7 , or R 1a , R 1b and R 1c are each bonded to R 2a , R 2b and R 2c , and the carbon atom bearing them -O-alkyl-O- is represented; R 3 is a hydrogen atom or an alkyl group; R 4 is hydrogen or a halogen atom or cyano group, -OR 5 , hydroxyalkyl, -COOR 5 , -NR 6 R 7 , -CONR 6 R 7 , -SO 2 -alkyl or -SO 2 -NR 6 R 7 , -NR 6 -COOR 5 , -NR 6 -COR 5 , -CO-NR 6 -alkyl-OR 5 ; R 5 , R 6 and R 7 are hydrogen atoms, alkyl or -alkylphenyl groups; R 8 is a hydrogen atom, a -SO 2 -alkyl group or a group of the formula -B-Het, wherein B may be absent or a bond, an oxygen atom or a -CO- or -SO 2- (CH 2 ) n -group And n is 0, 1 or 2 and Het is heteroaryl or heterocycloalkyl optionally substituted by alkyl, —SO 2 -alkyl and —COOR 5 groups. |