| abstract |
The present invention relates to a 15α, 16α-methylene-17-hydroxy-19-nor-17-pregna-4-en-3-one-21-carboxylic acid γ-lactone derivative having a progesterogenic effect. It has the formula (I) <Formula I> Wherein Z is selected from the group comprising oxygen, two hydrogen atoms, NOR and NNHSO 2 R, wherein R is hydrogen, C 1 -C 10 -alkyl, aryl, C 7 -C 20 -aralkyl, R 4 is hydrogen or halogen, and R 6a , R 6b together form methylene or 1,2-ethanediyl, or R 6a is hydrogen, R 6b is hydrogen, C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl or C 2 -C 10 -alkynyl, R 7 is hydrogen, C 1 -C 10 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 10 -Alkenyl, C 2 -C 10 -alkynyl, or R 6a is hydrogen, R 6b and R 7 together represent a bond, oxygen or methylene group, R 18 is hydrogen or C 1- C 3 -alkyl. The present invention also relates to solvates, hydrates, stereoisomers and salts of such derivatives. |