| abstract |
The present invention provides humanized antibodies that immunospecifically recognize human α9 integrins. Some of these antibodies inhibit the biological function of the α9 integrin, whereby various disorders or diseases associated with α integrin, such as cancer, eg growth and metastasis of cancer cells, and inflammatory diseases such as rheumatoid It has therapeutic effects against arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granulomas, inflammatory bowel disease (ulcerative colitis and Crohn's disease), autoimmune diseases and the like. |