abstract |
The present invention relates to a polypeptide derived from a highly conserved resion (HCR) I-III of CD99 and its analogs, ie, CD99, CD99L2, and PBDX, which is a kind of transmembrane protein. As a fusion protein, there is provided a polypeptide or a fusion protein thereof having the activity of inhibiting extravasation of leukocytes. The present invention also provides a polynucleotide encoding the polypeptide, a vector comprising the same, and a transformant transformed with the vector. The present invention also provides a pharmaceutical composition for preventing or treating an inflammatory disease comprising the polypeptide or a fusion protein thereof. |