http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20100088223-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3164a963ca21cec1151213cb1bb95e77 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-38 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0619 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70567 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate | 2009-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01079f12fc9a1bcc40ccaf420c86352e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e590f653c2073876d5a6106c5c92fa34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71895bdc11bda1ef171a9e436a23126c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbbc554058135563f702bbad8744eaf1 |
| publicationDate | 2010-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20100088223-A |
| titleOfInvention | Induction of Improved Dopamine Neurons Using Nurc1 Variant Expression |
| abstract | The present invention provides a method for inducing dopamine neurons comprising inducing gene expression in neural progenitor cells by producing a Nurr1 variant having significantly reduced Akt-phosphorylation by inducing mutations in the Akt-phosphorylation-conserved site of Nurr1 protein. to provide. In addition, the present invention is to induce mutations in the Akt-phosphorylation region of the Nurr1 protein, and to express the Nurr1 mutant which is capable of expressing the significantly reduced Akt-phosphorylation, and to express the Nurr1 variant in the neural precursor cells. It provides a group of dopamine neurons derived from neural progenitor cells. According to the present invention, inducing mutant protein expression in neural progenitor cells produces dopamine neurons that maintain the natural Nurr1 function while maintaining stable Nurr1 protein concentration. Dopamine neurons produced by the variant Nurr1 of the present invention are resistant to toxic stimuli and improve cell survival in vitro and in vivo even after transplantation in the rat brain. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180111318-A |
| priorityDate | 2009-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 464.