| abstract |
The present invention provides the ω-conotoxin so that the amino acid residues 11 and / or 12 are positioned in the secondary loop between cysteine residues 2 and 3 of the ω-conotoxin peptide represented by the following general formula I, respectively, so that Ile and Ala are located: A method of increasing the binding reversibility of an ω-conotoxin peptide to an N-type calcium channel comprising the step of preparing a peptide. The present invention also relates to novel ω-conotoxin peptides and pharmaceutical compositions having excellent properties with blocking activity and specificity for N-type calcium channels and significantly increased binding reversibility for N-type calcium channels. |