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publicationDate 2010-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20100084617-A
titleOfInvention Use of Effective Alkaloid Fractions from Mulberry Branches in the Preparation of Hypoglycemic Agents
abstract The present invention relates to an effective fraction of alkaloids, wherein the effective fraction is prepared from mulberry branches and the active ingredients of the fraction are compositions of alkaloids. The percentage of total alkaloids in the effective fraction, as determined by HPLC, is at least 50% by weight and the percentage of compound 1-deoxyzirimycin in the total alkaloids is at least 30% by weight. An effective fraction of the present invention is prepared in the following steps: Mulberry branches are extracted with a solvent and the extract is precipitated by alcohol precipitation or flocculation to remove impurities, then concentrated and purified by resin chromatography. . The present invention also relates to pharmaceutical compositions containing an effective fraction of alkaloids, and to the use of an effective fraction of alkaloids according to claims 1-4 in the preparation of hypoglycemic agents.
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