http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20100077508-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_799b6c8cb40ea97102dceda7bfe7b5c7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048 |
| filingDate | 2008-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0dd692cc0704f3a60ab6320d11d87d03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ccebb465000466d13db529504b9451c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62e28d63717c9372c428a96c9067384d |
| publicationDate | 2010-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20100077508-A |
| titleOfInvention | Methods and apparatus for preparing liposomes containing no amphotericin |
| abstract | The present inventionn n n Preparing a mixed solution comprising amphotericin B, phospholipids, and sterols;n n n Mixing an aqueous and supercritical fluid comprising water with the mixed solution to produce a supercritical fluid / aqueous emulsion; Andn n n After reaching an equilibrium state, the supercritical fluid is discharged under reduced pressure to form a liposome solution, thereby providing a method for preparing an amphotericin B-containing liposome preparation.n n n In addition, the present invention provides an apparatus for performing the manufacturing method. According to the production method of the present invention, it is possible to prepare a liposome having high encapsulation efficiency of amphotericin B, and excellent stability of the active ingredient and formulation stability of liposomes. In addition, the preparation method of amphotericin B-containing liposomes according to the present invention can be made by a simple device because the process is very simplified, economical mass production is possible. |
| priorityDate | 2008-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.