| abstract |
The present invention relates to (E) -N- {4- [3-chloro-4- (2-pyridinylmethoxy) anilino] -3-cyano-7-ethoxy-6-quinolinyl} -4- Processes for preparing (NERATINIB) in the form of maleate salts of (dimethylamino) -2-butenamide, in the form of crystalline maleate salts, related compounds, such as degradants, impurities and pharmaceutical compositions containing such maleate salts It is about. Maleate salts are useful for the treatment of cancer, particularly those affected by kinase of the epidermal growth factor receptor family. |