abstract |
The present invention relates to a microparticle system for delayed and controlled release of an active source (AP) in which the absorption window in vivo is essentially limited to the upper gastrointestinal tract, the system aiming for oral administration. The present invention provides a system that allows the active source to be well released by the 'time dependent' and 'pH dependent' dual mechanisms. Accordingly, the present invention provides a multi-microcapsule herbal oral preparation designed to ensure therapeutic efficacy, wherein the release of the active source is controlled by a dual release initiation mechanism of time onset and pH onset. The microcapsule system (200-600 μm) is a hydrophilic polymer A (Eudragit L) and a hydrophobic compound B (vegetable wax having a melting point of 40-90 ° C.), including a nucleus of an active source coated with a coating film (up to 40 wt%), wherein the weight ratio of B / A is 0.2-1.5 . In the microcapsules, at a constant pH 1.4, an incubation state of 1-5 hours is observed, and then the active source is released, thereby changing the pH from 6.8 to 6.8, thereby releasing the active source in vitro without incubation time. Has a dissolution mode ex vivo. |