| abstract |
MEANS TO SOLVE THE PROBLEM As a result of earnestly examining about the NAD (P) H oxidase inhibitor, the present inventors confirmed that the quinolone derivative which has an alkyl group substituted by a hetero atom etc. in 2nd position has favorable NAD (P) H oxidase inhibitory effect, Completed. Since the compound of the present invention has active oxygen species production inhibitory activity based on NAD (P) H oxidase inhibitory action, it can be used as a prophylactic and / or therapeutic agent for diabetes, glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like. |