| abstract |
Contacting a sample, potentially contaminated with PrP sc , with a target protein with a multimodal chromatography material; Setting buffer conditions such that the target protein is bound to the multimode chromatography material and PrP sc does not bind to the multimode chromatography material; And a method for separating and purifying the target protein by chromatography to remove or deplete prion (PrP sc ), comprising eluting the target protein. A method for isolating and purifying a target protein from which prion protein (PrP sc ) has been removed is provided. |