| abstract |
Preferred exemplary embodiments in the present application provide formulations and methods for delivering drugs, particularly abuse drugs, having an abuse drug that is substantially confined to the core and a non-use drug in the non-core region. These formulations have a reduced likelihood of abuse. In this formulation, preferably the abuse drug is an opioid and the non- abuse drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone and the non-abuse analgesic is acetaminophen. In certain preferred embodiments, the dosage form is resistant to solvent extraction, tampering, crushing or grinding. Certain embodiments of the present invention provide dosage forms that provide sustained controlled drug release after rapid initial release of the drug. |