| abstract |
Described herein are gamma secretase inhibitors of Formula (I) or pharmaceutically acceptable salts, solvates or esters thereof. In addition, a method of inhibiting gamma secretase using a compound of Formula 1.0, a method of treating Alzheimer's disease, a method of treating one or more neurodegenerative diseases, and in, on, or in a nervous tissue (eg, the brain) Surrounding it is described a method for inhibiting the deposition of amyloid protein (eg, amyloid beta protein). Formula I In the above formula (I) L 1 , n, X, Ar, Y, Z, Q and Q 1 are as defined herein. |