| abstract |
The present invention relates to a biologically active protein comprising at least two domains, wherein a first domain of the at least two domains comprises an amino acid sequence having and / or mediating the biological activity, wherein The second domain preferably comprises an amino acid sequence consisting of at least about 100 amino acid residues forming a random coil structure, wherein the random coil structure mediates increased in vivo and / or in vitro stability of the biologically active protein. . In addition, nucleic acid molecules encoding biologically active proteins of the invention, and vectors and cells comprising the nucleic acid molecules are disclosed. The present invention also provides specific uses of the biologically active proteins, nucleic acid molecules, vectors and cells of the invention as well as compositions comprising the compounds of the invention. |