abstract |
The present invention provides a method for preparing a stabilizing region comprising: (a) a structure stabilizing region comprising parallel, antiparallel or parallel and antiparallel amino acid strands formed with interstrand noncovalent bonds; And (b) target binding region I and target binding region II, each of which is bound to both ends of the structure stabilization site and includes randomly selected n and m amino acids, respectively. As related to a bipodal peptide binder that specifically binds to a containing target, and a method for preparing the same, the bipodal peptide binder of the present invention exhibits a very low level (eg, nM level) of K D value (dissociation constant), Very high affinity to the target. The bipodal peptide binder of the present invention not only has a use as a medicament, but also can be used for in vivo molecular imaging, in vitro cell imaging, and drug delivery targeting, and can be very useful as an escort molecule. |