| abstract |
Piperazinyl oxoalkyl tetrahydro-beta-carboline and related analogs thereof, and methods of making and using the same, are provided below: (I) Such compounds can generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful for treating various diseases in humans, domestic pets, and animal husbandry. Pharmaceutical compositions and methods of treatment, and methods of using such ligands to detect histamine H3 receptors (eg, receptor localization studies) are provided. |