| abstract |
The present invention provides the use of a mixed metal compound in the manufacture of a medicament relating to the neutralization or buffering of gastric acid, wherein the mixed metal compound is at least one trivalent metal selected from iron (III) and aluminum and magnesium, iron, zinc At least one divalent metal selected from calcium, lanthanum and cerium, wherein (A) the mixed metal compound is of formula (I): M II 1-a M III a O b A n- c .zH 2 O (I) wherein M II is at least one divalent metal; M III is at least one trivalent metal; A n- is at least one n-valent anion; 2 + a = 2b + ∑cn, ∑cn <0.9a, and z are 2 or less and / or (B) the mixed metal compound comprises (i) at least 50% by weight of the mixed metal compound ( Ii) from 3 to 12% by weight of non-chemically bound water by weight of the granular material, and (iii) up to 47% by weight of excipient by weight of the granular material. |