http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20100018059-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_333c51b9dae0166cf6cb26b7d623f616 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-08 |
| filingDate | 2008-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6daf0719374bcbe298afecb2779eb821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69bda033ef4f55ad034381d3f6da2bc4 |
| publicationDate | 2010-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20100018059-A |
| titleOfInvention | Process for preparing substituted heteroaromatics |
| abstract | The invention is characterized in that it is carried out in the presence of a cycloalkyl alkyl ether as a solvent, and possibly further solvents, A) Conversion reaction of halogenated heteroaromatics of Formula II using Grignard reagent of Formula III: <Formula II> (In the meal, X represents the meaning mentioned in formula (I), R 6 represents bromine, iodine or chlorine, R 1 , R 2 and R 3 have the meanings mentioned in formula I), <Formula III> R 4 MgHal (In the meal, R 4 has the meaning referred to in formula I, Hal is bromine, iodine or chlorine); or B) First, the conversion of the halogenated heteroaromatic of formula (II) to magnesium to the Grignard compound of formula (IIIa), followed by further conversion using the halogenated compound of formula (IV): <Formula IIIa> (In the meal, Hal is bromine, iodine or chlorine, X, and R 1 , R 2 and R 3 have the meanings mentioned in formula I), <Formula IV> R 4 Hal (In the meal, R 4 has the meaning referred to in formula I, Hal is bromine, iodine or chlorine) Wherein the conversion reaction A) or B) is carried out in the presence of Ni or Pd catalyst respectively) to a process for preparing substituted heteroaromatics of formula (I) <Formula I> In the formula, X represents oxygen, sulfur or NR 5 , where R 5 represents hydrogen, C 1 -C 20 -alkyl or C 5 -C 6 -aryl, R 4 represents C 1 -C 20 -alkyl, C 5 -C 6 -aryl or heteroaryl, R 1 , R 2 and R 3 represent hydrogen, halogen, C 1 -C 20 -alkyl, C 5 -C 6 -aryl or heteroaryl. The invention also describes the use of cycloalkyl alkyl ethers, in particular cyclopentyl methyl ether, in the Kumada reaction for the production of substituted heteroaromatics, in particular substituted thiophenes. |
| priorityDate | 2007-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.