| abstract |
The present invention selects and / or isolates peptides and / or polypeptides from libraries or repertoires (eg, display systems) of peptides and polypeptides that are resistant to degradation by proteases, such as proteases found in human GI tract or lung tissue. It is about a method of collecting. In general, the method provides a library or repertoire of peptides or polypeptides, combines the library or repertoire with a protease under conditions suitable for protease activity, and selects a peptide or polypeptide that is resistant to degradation by the protease and has the desired biological activity. And / or separate and / or recover. Selected peptides and polypeptides have utility as therapeutics, for example for treating diseases or disorders of human GI tract or lung tissue. |