| abstract |
It combines nerve axon elongation and angiogenic hyperplasia, and ischemic heart disease such as cerebral injuries such as head trauma or spinal cord injury, ischemic heart disease such as cerebral infarction, myocardial infarction or organic angina, or peripheral artery obstruction such as severe ischemia. As a provision of the compound which can adapt to the improvement of these diseases or these sequelae, following formula (I)n n n n n n n n The Nx group represents an aromatic 6-membered ring containing two nitrogen atoms, R 0 , R 1 , and R 2 each independently represent a hydrogen atom, an alkyl group, an amino group, and E is an oxygen atom. Or group -NR 8 (R 8 is an alkyl group or the like), n represents an integer of 0 to 5, X and Y are a bond number, a cycloalkyl group, -CO- or the like, and Q is a hydrogen atom or a phenyl group. It is a compound represented. |