| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7ddc4774cf5f8a0bda44a780d73c53d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-31 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6811
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-59 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate |
2009-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61a3c23e4299885994f97926e4d35df5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a49b24aa34dbe8a60f3ed8cfcc400985
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15f1242ae7146b6badc9bc6c9008134d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73a8d4cc16357235942e34e3fda3ffb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb0cff68b85685985230fb67f7263b4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8135763df1b691ccb42ee0db3a6ee103 |
| publicationDate |
2010-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20100010919-A |
| titleOfInvention |
Bioactive Polypeptide Drug Conjugates Using Non-peptidyl Polymers with Three-terminal Reactors |
| abstract |
The present invention relates to a protein conjugate with improved biopersistence and stability in which a physiologically active polypeptide, a three-arm non-peptidyl polymer and a dimer protein are covalently linked to each other, and a method for preparing the same. . The protein conjugate of the present invention maintains relatively high in vivo activity of the physiologically active polypeptides and peptides and significantly increases the blood half-life, which can be useful for developing sustained formulations of various physiologically active polypeptide drugs as well as conventional proteins. In the preparation of the conjugate, the production method can be efficiently used to improve the problems such as low production yield and loss of the raw material bioactive polypeptide, it has the advantage that the purification is easy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017052321-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101479937-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11434271-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180019634-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11168109-B2 |
| priorityDate |
2008-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |