| abstract |
The present invention relates to a process for preparing a compound of formula (IV):n n n n n n n n Wheren n n R 1 , R 2 , R 3 and R 4 , which may be the same or different, are each a hydrogen atom, a linear or branched (C 1 -C 6 ) alkyl group, a linear or branched (C 1 -C 6 ) alkoxy group, fluorine An atom, a chlorine atom, a protected amine group, a protected hydroxyl group, an alkoxycarbonyl group in which the alkoxy group is linear or branched (C 1 -C 6 ), or a CF 3 group, or R 1 = R 4 = H, R 2 And R 3 together with the carbon atoms having them form a 1,3-dioxolane group,n n n R 5 is a saturated or unsaturated linear or branched (C 1 -C 6 ) alkyl group, a linear or branched (C 1 -C 6 ) hydroxyalkyl group protected by a hydroxyl functional group, or R 7 is linear or branched ( a C 1 -C 6) alkyl group CO 2 R 7 group,n n n R 6 is a cyano group or a C0 2 R 8 group wherein R 8 is a linear or branched (C 1 -C 6 ) alkyl group.n n n The invention also relates to the use of said compounds in the synthesis of ivabradine, and addition salts and hydrates thereof with pharmaceutically acceptable acids thereof. |