http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20100004736-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e059c2b5134637de8ad38ef16a06c64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2968f608f8af0b0214338bfdb800aa6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-483 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-483 |
| filingDate | 2008-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64cf802f53e4b375a2c19f2817a93d08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9acea67ac0e6105c45d76740df30bee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50f0f5b5b3d628a9f4aff4ea5ab28f3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8fb6f5db33b0b75bd9772b38974d9f8 |
| publicationDate | 2010-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20100004736-A |
| titleOfInvention | Composition for the prevention or treatment of aberrant proliferative vascular disease comprising engraver thorn extract |
| abstract | The present invention relates to a composition for the prevention or treatment of aberrant proliferative vascular disease comprising a sculpted thorn extract as an active ingredient. Composition of the present invention comprising a bark thorn extract as an active ingredient exhibits excellent cytotoxicity against smooth muscle cells, G2 / M stage by inhibiting the expression and activity of cell cycle regulators Cdc25c, Cdc2 and cyclin B It inhibits the activity of the transcription factors NF-κB and AP-1 and inhibits the activity of MMP-9 in smooth muscle cells, effectively inhibiting the migration of cells, and also inhibiting MAPK (mitogen-) such as ERK, p38MAP kinase and JNK. Induces apoptosis of cells by promoting the activity of activated protein kinase. In addition, the composition of the present invention is excellent in safety because it contains a bark thorn extract has been used as a herbal medicine as an active ingredient for a long time. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101319552-B1 |
| priorityDate | 2008-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 128.